Colostrum shown specific antibodies to many bacteria and virus

The following research study abstracts shown the promising potential of bovine lactoferrin. These abstracts are for information sharing purposes only and do not intend to suggest or imply that products containing Colostrunin can prevent, treat or cure any diseases.

Lactoferrin, a component of Colostrum can inhibit Enterovirus 71 (EV71) which causes serious complication in hand, foot and mouth disease. EV 71 can cause encephalitis, the inflammation of the brain and myocarditis, the inflammation of the heart muscle.

See research below...

Antiviral Res. 2005 Jul;67(1):31-7.

Lactoferrin inhibits enterovirus 71 infection by binding to VP1 protein and host cells.

Weng TY, Chen LC, Shyu HW, Chen SH, Wang JR, Yu CK, Lei HY, Yeh TM.

Source

Department of Medical Laboratory Sciences and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC.

Abstract

The antiviral activities of bovine lactoferrin (LF) against enterovirus 71 (EV71) were studied both in vitro and in vivo. LF protected both human rhabdomyosarcoma and neuroblastoma SK-N-SH cell lines from EV71 infection when it was added at the same time, before, or within 30min after EV71 infection. Using enzyme-linked immunosorbent assay-based binding assay and indirect fluorescent stain, we found that LF could bind to the target cells. Furthermore, it was found that LF could bind to the VP1 protein of EV71, which was blocked in the presence of anti-VP1 antibody. In addition, LF could induce IFN-alpha expression of SK-N-SH cells and inhibit EV71-induced IL-6 production. Finally, LF protected mice against lethal EV71 challenge. Taken together, these results suggest that LF can inhibit EV71 infection by interacting with both EV71 and host cells.

PMID: 15916817 [PubMed - indexed for MEDLINE] US National Library of Medicine, National Institutes of Health.

PATHOGEN	DISEASE CONDITION
Bacillus cereus	Food Poisoning, Mastitis
Campylobacter jejuni	Food Poisoning
Candida albicans	Thrush - Yeast Infection
Clostridium difficile	Food Poisoning
Escherischia coli	Commensal Bacteria
Escherischia coli 0157:H7	Food Poisoning
Haemophilus influenzae	Bacterial Meningitis - can be fatal
Helicobacter Pylori	Stomach Ulcers usually the cause of Stomach cancer
Klebsiella pneumoniae	Pneumonia, Urinary Tract Infection
Listeria monocytogenes	Food poisoning - can be fatal
Propionibacterium acnes	Acne
Salmonella enteritidis	Food Poisoning - can be fatal
Staphylococcus aureus	Pneumonia, Osteomyelitis, Carditis, Meningitis, Arthritis, Toxic Shock Syndrome,Antibiotic Resistant - MRSA
Staphylococcus epidermis	Multiple Antibiotic Resistance (MAR)
Streptococcus agalactiae	Mastitis, Bacteremia, Meningitis, Pneumonia - can be fatal
Steprococcus mutans	Periodontal disease, Tooth decay, Arteriosclerosis, Endocarditis
Steptococcus pygenes	Strep Throat, Flesh-eating Bacteria, Myositis
Step Shock Syndrome	Rheumatic Fever, Kidney disease
Yersinia enterocolitica	Food Poisoning, Scepticemia - can be fatal

Is there any possibility of protecting women from the Human Papillomaviru (HPV), a risk factor of getting cervical cancer? Bovine Colostrum Lactoferrin shown to be a potent inhibitor of HPV entry. See study paper below...

Antiviral Res. 2004 Oct;64(1):63-8.

Lactoferrin inhibits human papillomavirus binding and uptake in vitro.

Drobni P, Näslund J, Evander M.

Source

Department of Virology, Umeå University, SE-901 85 Umeå, Sweden. Peter.drobni@climi.umu.se

Abstract

Lactoferrin (LF), a member of the transferrin family, is a bi-globular protein secreted in milk, saliva, tears, seminal fluid, endocervix and vaginal secretions. LF is an important player in the defence against pathogenic microorganisms and has also been shown to have activity against several viruses including herpesvirus, adenovirus, rotavirus and poliovirus. The antiviral activity of LF is directed against the early steps of viral infection and the LF antiviral effect against herpesvirus is mediated through LF binding to the herpesvirus receptor heparan sulfate. Human papillomavirus (HPV) causes genital warts and is a prerequisite for cervical cancer. HPV can also use heparan sulfate on the cell surface as a receptor. We studied the inhibition by LF on HPV entry by incubating HaCaT cells and HPV-16 virus-like particles (VLPs) with either human (HLF) or bovine lactoferrin (BLF). LF inhibited internalization of HPV-16 particles using CFDA-SE-labelled VLPs that only fluoresce after internalisation. By using a western blot assay we also found dose-dependent LF inhibition of HPV-16 VLP binding to the HaCaT cell surface. BLF was a more potent inhibitor of HPV entry than human LF. It was also clear that LF acted early in the HPV uptake process.

PMID: 15451180 [PubMed - indexed for MEDLINE] US National Library of Medicine, National Institutes of Health.

A recent study by Otago University, New Zealand, colostrum from pasture-fed New Zealand cows shown specific antibodies to the following microbes.