Immunomodulatory effects of bovin colostrum

The following research study abstracts shown the immunomodulatory effects of bovine colostrum. These abstracts are for information sharing purposes only and do not intend to suggest or imply that products containing Colostrunin can prevent, treat or cure any diseases.

“Bovine Colostrum could also represent an inexpensive therapeutic tool in prevention and treatment of several human microbial infections, including influenza” according to this study.

New Microbiol. 2007 Oct;30(4):447-54.

Immunomodulatory effects of bovine colostrum in human peripheral blood mononuclear cells.

Biswas P, Vecchi A, Mantegani P, Mantelli B, Fortis C, Lazzarin A.

Source

San Raffaele Scientific Institute, Milan, Italy, Lab. of Clinical Immunology/Clinic of Infectious Diseases. biswas.priscilla@hsr.it

Abstract

Human and bovine colostrum (BC) contain a remarkable amount of bioactive substances, including antibodies towards many common pathogens of the intestinal and respiratory tract as well as growth factors, vitamins, cytokines and other proteic, lipidic and glucidic factors. In this study we investigated whether BC had any immunomodulatory effect on human peripheral blood mononuclear cells (PBMC) from healthy donors. To this aim we focused on the production of IL-12 and IFN-gamma, cytokines involved in the Th1 polarization required for a successful immune response towards intracellular pathogens, such as bacteria and viruses. BC induced a dose-dependent production of IL-12 by CD14+ monocytes, but was unable to induce IFN-gamma production. However, BC differentially affected stimuli-induced IFN-gamma production: it enhanced IFN-gamma in response to weak antigenic stimulation and it inhibited IFN-gamma in response to strong antigenic stimulation. These effects were not dose-dependent. We also measured PBMC proliferation, which was substantially unaffected by BC. Our data suggest that the Th1-promoting activity of BC could contribute, together with the antibodies, to the protective effect of BC on the offspring. BC could also represent an inexpensive therapeutic tool in prevention and treatment of several human microbial infections, including influenza.

PMID: 18080681 [PubMed - indexed for MEDLINE] US National Library of Medicine, National Institutes of Health.

Pol Merkur Lekarski. 2009 Mar;26(153):234-8.

[Immunomodulatory proteins in colostrum].

[Article in Polish]

Płusa T.

Source

Department of Internal Medicine, Pneumonology and Allergology, Central Clinical Hospital of the Ministry of National Defense, Military Institute of Health Services in Warsaw, Poland. tplusa@wim.mil.pl

Abstract

The value of bovine colostrums is documented in clinical observations and supported by large database. An antibacterial effect and modulation of the immune response are accepted. The wide spectrum of the activity of a lactoferrin or a proline-rich polypeptide complex was confirmed in experimental and clinical studies. Moreover, a high concentration of immunoglobulins in bovine colostrum gives exceptional opportunity for use it as a support in immunodeficiency treatment.

PMID: 19388540 [PubMed - indexed for MEDLINE] US National Library of Medicine, National Institutes of Health.